Joe E. Ross ... Officer Gunther Toody 
Fred Gwynne ... Officer Francis Muldoon

The TV show's police cars used on location shots were actually bright red but on black and white film would appear dark, similar to that of real NYPD RMP units of that era (black and green with a white roof and trunk). Hence filmmakers achieved a realistic appearance without alarming bystanders during production.

Fred Gwynne and Al Lewis would later appear together again in The Munsters (1964-1966). Much of the script was written by Nat Hiken. Joe E. Ross and Beatrice Pons were teamed once more as husband and wife (Ross played the part of the witless Rupert Ritzik in Bilko, Pons his wife Emma). Silvia Schnauser (Charlotte Rae) also appeared in Sergeant Bilko as "The Twitch", and Gwynne made an appearance as a prodigious eater.